Joint Supplement Comparison for Horses Dose Amount Loading Dose Approved for Pets Hyaluronic Acid (HA) Methyl Sulfonyl Methane (MSM) Glucosamine Hydrochloride Glucosamine Sulfate Chondroitin Sulfate Yucca Grape Seed Extract Devils Claw Other Ingredients Cosequin ASU Joint Supplement for Horses 1/2-2 scoops (16.2- 32.4 gm) 2-3 scoops for 2-4 weeks No 10,000 mg per 32.4 gm 14,400 mg per 32.4 gm 2,400 mg per 32.4 gm 2,100 mg ASU powder, 610 mg ascorbic acid & 100 mg manganese Cosequin ASU Plus Joint Supplement for Horses 1/2-1 scoop (17 gm) 1-2 scoops for 2-4 weeks No 100 mg per 34 gm 10,000 mg per 34 gm 14,400 mg per 34 gm 2,400 mg per 34 gm 2,100 mg ASU powder and 30 mg total catechins (from green tea extract) Cosequin Optimized with MSM for Horses 1/2-1 scoop (16.5 gm) 1-2 scoops for 2-4 weeks No 5,000 mg per 16.5 gm 7,200 mg per 16.5 gm 1,200 mg per 16.5 gm 32 mg manganese Cosequin Original Joint Health Supplement for Horses 1-2 scoops (3.3 gm) 2-4 scoops twice daily for 2-4 weeks No 1,800 mg per 3.3 gm 600 mg per 3.3 gm 16 mg manganese dac Optimum Flex Plus Joint Supplement for Horses 1 oz 2 oz for 30 days No 150 mg per oz 8,500 mg per oz 2,000 mg per oz 2,000 mg per oz 1,000 mg per oz 250 mg ascorbic acid (vitamin C, 18 mg manganese proteinate, 15 mg zinc proteinate and 10 mg copper proteinate DC-Y Devils Claw Yucca Pellet Supplement for Horses 1/2-1 oz No 2,500 mg per oz 2,097 mg per oz Devils Claw Plus Joint Support for Horses 1-2 scoops (30 gm) No 3,200 mg per 30 gm 500 mg per 30 gm 2,600 mg per 30 gm 1,475 mg of a Proprietary Blend of cats claw, turmeric, white willow and feverfew herb powders; 1,000 mg ascorbic acid; 500 mg boswellia and 500 mg pantothenic acid DuraFlex EQ Equine Joint Supplement - Liquid 1 oz 2 oz for first 10 days No 25 mg per oz 2,050 mg per oz 3,000 mg per oz 3,000 mg per oz 250 mg per oz DuraFlex EQ Equine Joint Supplement - Pellets 1 scoop (1 oz) 2 oz for first 14-21 days No 60 mg per oz 1,000 mg per oz 5,000 mg per oz 250 mg per oz 250 mg manganese, 60 mg zinc sulfate, 14 mg hesperidin, 20,000 IU vitamin A and Yea-Sacc 1026 Effortless HA Joint Supplement 1/2 oz 1 ounce for first 10 days Yes - Multi- species 350 mg per oz Ascorbic acid, glycerine, propylene glycol, vitamin E oil and yucca schidigera Equinyl Combo Horse Supplement 1 oz 2 oz daily for 1-2 weeks No 7,500 mg per oz 5,000 mg per oz 875 mg per oz 3,000 mg ComfortX, 1,575 mg Ester C, 65 mg zinc, 50 mg manganese and 13 mg copper Equinyl Joint Formula w/HA Horse Supplement 1 oz 2 oz daily for 1-2 weeks No 30 mg per oz 7,500 mg per oz 5,000 mg per oz 875 mg per oz 3,000 mg ComfortX, 1,575 mg Ester C, 65 mg zinc, 50 mg manganese and 13 mg copper Disclaimer: The information shown here has been gathered from many sources and with great care. Recognizing, however, the possibility of human and typographical errors in transposing such a large amount of technical information, PBS Animal Health hereby disclaims responsibility. Updated 7/20/22